Off-label, but not experimental. Ketamine has been an anesthetic in widespread clinical use since 1970, with decades of safety data from operating rooms and emergency departments around the world. Its application to treatment-resistant depression and other psychiatric conditions is off-label — meaning the FDA has not granted specific approval for these psychiatric uses, even though a substantial and growing research base supports them. NeuroSpa Citrus Park is upfront about this regulatory distinction, and your psychiatrist walks through it in detail during your consultation.
Insurance coverage is variable, and cash-pay is an option. Because IV ketamine is off-label for psychiatric use, insurance coverage is less consistent than it is for Spravato or for TMS. Some Citrus Park patients bill through commercial insurance with prior authorization, others pay out of pocket, and the right path depends on your specific plan and financial situation. The Citrus Park HQ admin team handles off-label benefits verification end-to-end, usually within one business day, explains what your plan will and will not cover, and provides a written out-of-pocket estimate before any infusion is scheduled — so you can choose the billing path that makes sense for you before your first visit.